Jump to main content
Jump to site search

Issue 4, 2012
Previous Article Next Article

Site-selective modification of proteins for the synthesis of structurally defined multivalent scaffolds

Author affiliations

Abstract

A combination of classical site-directed mutagenesis, genetic code engineering and bioorthogonal reactions delivered a chemically modified barstar protein with one or four carbohydrates installed at specific residues. These protein conjugates were employed in multivalent binding studies, which support the use of proteins as structurally defined scaffolds for the presentation of multivalent ligands.

Graphical abstract: Site-selective modification of proteins for the synthesis of structurally defined multivalent scaffolds

Back to tab navigation

Supplementary files

Publication details

The article was received on 28 Sep 2011, accepted on 17 Oct 2011 and first published on 09 Nov 2011


Article type: Communication
DOI: 10.1039/C1CC16039G
Chem. Commun., 2012,48, 522-524

  •   Request permissions

    Site-selective modification of proteins for the synthesis of structurally defined multivalent scaffolds

    L. M. Artner, L. Merkel, N. Bohlke, F. Beceren-Braun, C. Weise, J. Dernedde, N. Budisa and C. P. R. Hackenberger, Chem. Commun., 2012, 48, 522
    DOI: 10.1039/C1CC16039G

Search articles by author

Spotlight

Advertisements