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Issue 6, 2012
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A multi-component domino reaction for the direct access to polyfunctionalized indolesvia intermolecular allylic esterification and indolation

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Abstract

A novel multi-component reaction for the synthesis of polyfunctionalized indoles and bis-indoles has been established. The reaction pathways were controlled by varying enamines with different substitution patterns to give polyfunctionalized indoles and bis-indoles selectively. The reaction proceeds at a fast speed within 15–30 min with water as the major byproduct, which makes work-up convenient.

Graphical abstract: A multi-component domino reaction for the direct access to polyfunctionalized indolesvia intermolecular allylic esterification and indolation

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Article information


Submitted
23 Sep 2011
Accepted
18 Oct 2011
First published
31 Oct 2011

Chem. Commun., 2012,48, 808-810
Article type
Communication

A multi-component domino reaction for the direct access to polyfunctionalized indolesvia intermolecular allylic esterification and indolation

B. Jiang, M. Yi, F. Shi, S. Tu, S. Pindi, P. McDowell and G. Li, Chem. Commun., 2012, 48, 808
DOI: 10.1039/C1CC15913E

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