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Issue 10, 2012
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Effect of O-glycosylation and tyrosinesulfation of leech-derived peptides on binding and inhibitory activity against thrombin

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Abstract

Synthesis of sulfated and unsulfated (glyco)peptide fragments of Hirudin P6 (a potent anticoagulant from the leech Hirudinaria manillensis) is described. The effect of O-glycosylation and tyrosine sulfation on thrombin binding and peptidolytic activity was investigated, together with the inhibition of fibrinogen cleavage.

Graphical abstract: Effect of O-glycosylation and tyrosine sulfation of leech-derived peptides on binding and inhibitory activity against thrombin

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Supplementary files

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Submitted
02 Aug 2011
Accepted
07 Nov 2011
First published
23 Nov 2011

Chem. Commun., 2012,48, 1547-1549
Article type
Communication

Effect of O-glycosylation and tyrosine sulfation of leech-derived peptides on binding and inhibitory activity against thrombin

Y. S. Y. Hsieh, D. Taleski, B. L. Wilkinson, L. C. Wijeyewickrema, T. E. Adams, R. N. Pike and R. J. Payne, Chem. Commun., 2012, 48, 1547
DOI: 10.1039/C1CC14773K

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