Issue 10, 2012
From the journal:

Chemical Communications

Effect of O-glycosylation and tyrosinesulfation of leech-derived peptides on binding and inhibitory activity against thrombin†‡

Yves S. Y. Hsieh,a   Deni Taleski,a   Brendan L. Wilkinson,a   Lakshmi C. Wijeyewickrema,b   Ty E. Adams,c   Robert N. Pikeb  and  Richard J. Payne*a  

* Corresponding authors

a School of Chemistry, The University of Sydney, NSW 2006, Australia
E-mail: richard.payne@sydney.edu.au
Fax: +61 2 9351 3329
Tel: +61 2 9351 5877

b Department of Biochemistry and Molecular Biology, Monash University, VIC 3800, Australia

c Department of Haematology, University of Cambridge, Cambridge Institute for Medical Research, Cambridge CB2 0XY, United Kingdom

Abstract

Synthesis of sulfated and unsulfated (glyco)peptide fragments of Hirudin P6 (a potent anticoagulant from the leech Hirudinaria manillensis) is described. The effect of O-glycosylation and tyrosine sulfation on thrombin binding and peptidolytic activity was investigated, together with the inhibition of fibrinogen cleavage.

Graphical abstract: Effect of O-glycosylation and tyrosine sulfation of leech-derived peptides on binding and inhibitory activity against thrombin

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Article information

DOI
https://doi.org/10.1039/C1CC14773K
Article type
Communication
Submitted
02 Aug 2011
Accepted
07 Nov 2011
First published
23 Nov 2011

Chem. Commun., 2012,48, 1547-1549

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Effect of O-glycosylation and tyrosine sulfation of leech-derived peptides on binding and inhibitory activity against thrombin

Y. S. Y. Hsieh, D. Taleski, B. L. Wilkinson, L. C. Wijeyewickrema, T. E. Adams, R. N. Pike and R. J. Payne, Chem. Commun., 2012, 48, 1547 DOI: 10.1039/C1CC14773K

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