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Issue 10, 2012
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Effect of O-glycosylation and tyrosine sulfation of leech-derived peptides on binding and inhibitory activity against thrombin

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Abstract

Synthesis of sulfated and unsulfated (glyco)peptide fragments of Hirudin P6 (a potent anticoagulant from the leech Hirudinaria manillensis) is described. The effect of O-glycosylation and tyrosine sulfation on thrombin binding and peptidolytic activity was investigated, together with the inhibition of fibrinogen cleavage.

Graphical abstract: Effect of O-glycosylation and tyrosine sulfation of leech-derived peptides on binding and inhibitory activity against thrombin

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The article was received on 02 Aug 2011, accepted on 07 Nov 2011 and first published on 23 Nov 2011


Article type: Communication
DOI: 10.1039/C1CC14773K
Chem. Commun., 2012,48, 1547-1549

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    Effect of O-glycosylation and tyrosine sulfation of leech-derived peptides on binding and inhibitory activity against thrombin

    Y. S. Y. Hsieh, D. Taleski, B. L. Wilkinson, L. C. Wijeyewickrema, T. E. Adams, R. N. Pike and R. J. Payne, Chem. Commun., 2012, 48, 1547
    DOI: 10.1039/C1CC14773K

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