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A convenient method to prepare supramolecular bioconjugates in a facile and scalable manner is by a modular approach, whereby self-assembling units and peptides are coupled using oxime chemistry. We here report syntheses of bioactive ureidopyrimidinone-based peptide conjugates, and their resultant self-assembly into fibrous structures.

Graphical abstract: Modular synthesis of supramolecular ureidopyrimidinone–peptide conjugates using an oxime ligation strategy

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