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Issue 10, 2012
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Maleimide-functionalised organoruthenium anticancer agents and their binding to thiol-containing biomolecules

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Abstract

RuII(arene) anticancer compounds with maleimide functionality were prepared to allow selective interaction with thiol-containing biomolecules and thereby enforcing the selective delivery of the compounds to the tumour.

Graphical abstract: Maleimide-functionalised organoruthenium anticancer agents and their binding to thiol-containing biomolecules

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Supplementary files

Article information


Submitted
31 Jul 2011
Accepted
27 Sep 2011
First published
14 Oct 2011

Chem. Commun., 2012,48, 1475-1477
Article type
Communication

Maleimide-functionalised organoruthenium anticancer agents and their binding to thiol-containing biomolecules

M. Hanif, A. A. Nazarov, A. Legin, M. Groessl, V. B. Arion, M. A. Jakupec, Y. O. Tsybin, P. J. Dyson, B. K. Keppler and C. G. Hartinger, Chem. Commun., 2012, 48, 1475 DOI: 10.1039/C1CC14713G

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