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Issue 10, 2012
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Maleimide-functionalised organoruthenium anticancer agents and their binding to thiol-containing biomolecules

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Abstract

RuII(arene) anticancer compounds with maleimide functionality were prepared to allow selective interaction with thiol-containing biomolecules and thereby enforcing the selective delivery of the compounds to the tumour.

Graphical abstract: Maleimide-functionalised organoruthenium anticancer agents and their binding to thiol-containing biomolecules

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Supplementary files

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The article was received on 31 Jul 2011, accepted on 27 Sep 2011 and first published on 14 Oct 2011


Article type: Communication
DOI: 10.1039/C1CC14713G
Citation: Chem. Commun., 2012,48, 1475-1477

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    Maleimide-functionalised organoruthenium anticancer agents and their binding to thiol-containing biomolecules

    M. Hanif, A. A. Nazarov, A. Legin, M. Groessl, V. B. Arion, M. A. Jakupec, Y. O. Tsybin, P. J. Dyson, B. K. Keppler and C. G. Hartinger, Chem. Commun., 2012, 48, 1475
    DOI: 10.1039/C1CC14713G

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