Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

Scheduled maintenance work on Wednesday 22nd May 2019 from 11:00 AM to 1:00 PM (GMT).

During this time our website performance may be temporarily affected. We apologise for any inconvenience this might cause and thank you for your patience.

Issue 10, 2012
Previous Article Next Article

Thioamide quenching of intrinsic protein fluorescence

Author affiliations


Thioamides quench tryptophan and tyrosine fluorescence in a distance-dependent manner and thus can be used to monitor the binding of thioamide-containing peptides to proteins. Since thioamide analogs of the natural amino acids can be synthetically incorporated into peptides, they can function as minimally-perturbing probes of protein/peptide interactions.

Graphical abstract: Thioamide quenching of intrinsic protein fluorescence

Back to tab navigation

Supplementary files

Publication details

The article was received on 31 Jul 2011, accepted on 25 Aug 2011 and first published on 12 Sep 2011

Article type: Communication
DOI: 10.1039/C1CC14708K
Chem. Commun., 2012,48, 1550-1552

  •   Request permissions

    Thioamide quenching of intrinsic protein fluorescence

    J. M. Goldberg, R. F. Wissner, A. M. Klein and E. J. Petersson, Chem. Commun., 2012, 48, 1550
    DOI: 10.1039/C1CC14708K

Search articles by author