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Issue 10, 2012
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Membrane labeling and immobilization viacopper-free click chemistry

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Abstract

Copper-free click chemistry was employed to derivatize membrane bilayers. This approach uses an azido-lipid conjugate presented on liposomes, which can be labeled in bioorthogonal fashion viacyclooctyne-tagged reagents. An immobilization-based approach using streptavidin-coated microplates was exploited to evaluate membrane derivatization.

Graphical abstract: Membrane labeling and immobilization viacopper-free click chemistry

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Publication details

The article was received on 20 Jul 2011, accepted on 21 Sep 2011 and first published on 03 Oct 2011


Article type: Communication
DOI: 10.1039/C1CC14415D
Citation: Chem. Commun., 2012,48, 1431-1433

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    Membrane labeling and immobilization viacopper-free click chemistry

    H. E. Bostic, M. D. Smith, A. A. Poloukhtine, V. V. Popik and M. D. Best, Chem. Commun., 2012, 48, 1431
    DOI: 10.1039/C1CC14415D

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