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Issue 10, 2012
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Diverse organo-peptide macrocyclesvia a fast and catalyst-free oxime/intein-mediated dual ligation

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Abstract

Macrocyclic Organo-Peptide Hybrids (MOrPHs) can be prepared from genetically encoded polypeptidesvia a chemoselective and catalyst-free reaction between a trifunctional oxyamino/amino-thiol synthetic precursor and an intein-fusion protein incorporating a bioorthogonal keto group.

Graphical abstract: Diverse organo-peptide macrocyclesvia a fast and catalyst-free oxime/intein-mediated dual ligation

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Publication details

The article was received on 15 Jun 2011, accepted on 11 Aug 2011 and first published on 07 Sep 2011


Article type: Communication
DOI: 10.1039/C1CC13533C
Citation: Chem. Commun., 2012,48, 1461-1463

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    Diverse organo-peptide macrocyclesvia a fast and catalyst-free oxime/intein-mediated dual ligation

    M. Satyanarayana, F. Vitali, J. R. Frost and R. Fasan, Chem. Commun., 2012, 48, 1461
    DOI: 10.1039/C1CC13533C

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