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Abstract | Cited by

Macrocyclic Organo-Peptide Hybrids (MOrPHs) can be prepared from genetically encoded polypeptidesvia a chemoselective and catalyst-free reaction between a trifunctional oxyamino/amino-thiol synthetic precursor and an intein-fusion protein incorporating a bioorthogonal keto group.

Graphical abstract: Diverse organo-peptide macrocyclesvia a fast and catalyst-free oxime/intein-mediated dual ligation

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