Multiwalled carbon nanotube paste electrode as an easy, inexpensive and highly selective sensor for voltammetric determination of Risperidone

Abstract

A carbon paste electrode (CPE) modified with multi-walled carbon nanotube (MWCNT) was proposed for determination of Risperidone (Risp). The method was based on adsorptive accumulation of the Risp on to paste electrode, followed by reduction of the accumulated species by voltammetric scan. The parameters influencing the peak current were optimized. Under the optimum conditions, the electrode established linear response over a wide range of Risp concentrations (0.04 to 10 μmol L⁻¹), the detection limit was 0.012 μmol L⁻¹ (after 150 s accumulation). The method was applied to the determination of Risp in a pharmaceutical preparation and in human serum samples, and satisfactory results were obtained.