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Issue 21, 2012
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Tracing nanoparticles in vivo: a new general synthesis of positron emitting metal oxide nanoparticles by proton beam activation

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Abstract

The synthesis of 18F-labelled positron emitting NPs by direct irradiation of 18O-enriched aluminum oxide NPs with 16 MeV protons is reported. Biodistribution studies of the labelled particles after intravenous administration were performed in male rats using positron emission tomography. The simple and general activation strategy can be applied to any in situ prepared core metal oxide particle for direct use or subsequent bio-compatible coating or encapsulation followed by functionalization.

Graphical abstract: Tracing nanoparticles in vivo: a new general synthesis of positron emitting metal oxide nanoparticles by proton beam activation

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Publication details

The article was received on 25 Jun 2012, accepted on 24 Aug 2012 and first published on 28 Aug 2012


Article type: Communication
DOI: 10.1039/C2AN35863H
Citation: Analyst, 2012,137, 4902-4906

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    Tracing nanoparticles in vivo: a new general synthesis of positron emitting metal oxide nanoparticles by proton beam activation

    C. Pérez-Campaña, V. Gómez-Vallejo, A. Martin, E. San Sebastián, S. E. Moya, T. Reese, R. F. Ziolo and J. Llop, Analyst, 2012, 137, 4902
    DOI: 10.1039/C2AN35863H

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