Issue 4, 2012
From the journal:

Analyst

Spectrophotometric detection of tyrosinase activity based on boronic acid-functionalized gold nanoparticles†

Sa Li,a   Langyong Mao,a   Yaping Tian,a   Joseph Wangb  and  Nandi Zhou*a  

* Corresponding authors

a The Key Laboratory of Industrial Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi, China
E-mail: zhounandi@jiangnan.edu.cn
Fax: +86 510 85918116
Tel: +86 510 85918116

b Department of NanoEngineering, University of California at San Diego, La Jolla, CA, USA

Abstract

A spectrophotometric method for the detection of tyrosinase activity is developed by utilizing the product-triggered aggregation of boronic acid-functionalized gold nanoparticles. Based on the changes of absorbance in UV-visible spectra, the assay shows extremely high sensitivity and lowered limit of detection of 1 × 10−10 u mL−1.

Graphical abstract: Spectrophotometric detection of tyrosinase activity based on boronic acid-functionalized gold nanoparticles

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Supplementary files

Article information

DOI
https://doi.org/10.1039/C2AN16085D
Article type
Communication
Submitted
09 Nov 2011
Accepted
15 Dec 2011
First published
03 Jan 2012

Analyst, 2012,137, 823-825

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Spectrophotometric detection of tyrosinase activity based on boronic acid-functionalized gold nanoparticles

S. Li, L. Mao, Y. Tian, J. Wang and N. Zhou, Analyst, 2012, 137, 823 DOI: 10.1039/C2AN16085D

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