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Issue 42, 2012
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Soft biodegradable polymersomes from caprolactone-derived polymers

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Abstract

Polymersomes have promise for advanced theranostic delivery. We report here the design and characterization of a series of block copolymers that assemble into soft, bioresorbable, and non-toxic vesicles. The polymers are based on poly(ethylene glycol)–poly(caprolactone), but the caprolactone (CL) is copolymerized with a second monomer, 1,4,8-trioxaspiro-[4,6]-9-undecanone (TOSUO). Because TOSUO polymers have no crystalline character, copolymerizing TOSUO with CL should reduce the crystallinity of the polymersomes. After synthesizing polymers with different ratios of CL to TOSUO, we found that all copolymers assemble into both micron and nano-metric vesicles. Increasing the TOSUO content of the copolymer reduces the polymer crystalline melting temperature and the area expansion modulus of vesicle membranes. Membranes with partial crystalline structure exhibit hysteresis in the tension versus strain curve during aspiration. Vesicles are not cytotoxic and exhibit first-order release of encapsulated gemcitabine. These materials are promising for the development of deformable, biodegradable polymersomes for biomedical applications.

Graphical abstract: Soft biodegradable polymersomes from caprolactone-derived polymers

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Article information


Submitted
01 Jun 2012
Accepted
03 Aug 2012
First published
04 Sep 2012

Soft Matter, 2012,8, 10853-10862
Article type
Paper

Soft biodegradable polymersomes from caprolactone-derived polymers

J. S. Katz, K. A. Eisenbrown, E. D. Johnston, N. P. Kamat, J. Rawson, M. J. Therien, J. A. Burdick and D. A. Hammer, Soft Matter, 2012, 8, 10853
DOI: 10.1039/C2SM26275D

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