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Issue 18, 2012

Supramolecular hydrogels based on antimycobacterial amphiphiles

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Abstract

Synthetic modification of antimycobacterial 4-alkoxy-anilines yields low molecular weight amphiphiles. The bioactivity is retained in these amphiphiles and shows alkyl chain length specificity. The self-assembly behaviour in aqueous media was investigated. It was found that several of these new compounds are capable of forming thermoreversible supramolecular hydrogels in alkaline aqueous media. The initial drug can be released from the hydrogel by thermal hydrolysis.

Graphical abstract: Supramolecular hydrogels based on antimycobacterial amphiphiles

Supplementary files

Article information


Submitted
23 Dec 2011
Accepted
15 Mar 2012
First published
29 Mar 2012

Soft Matter, 2012,8, 4873-4876
Article type
Communication

Supramolecular hydrogels based on antimycobacterial amphiphiles

A. Bernet, M. Behr and H. Schmidt, Soft Matter, 2012, 8, 4873 DOI: 10.1039/C2SM07456G

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