Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.


Issue 11, 2012
Previous Article Next Article

Lipid membrane curvature induced by distearoyl phosphatidylinositol 4-phosphate

Author affiliations

Abstract

In this paper we present evidence that phosphatidylinositol 4-phosphate induces curvature in biological membranes. The phase behaviour of mixtures of distearoylphosphatidylinositol 4-phosphate (DSPIP) and dioleoylphosphatidylcholine (DOPC) as a function of pressure and temperature has been studied using small-angle X-ray scattering and in the presence of biologically relevant magnesium concentrations. Our results demonstrate that at physiologically relevant concentrations (2 mol%), DSPIP is capable of inducing the formation of the inverse hexagonal phase (HII) over a wide range of conditions. This result has implications for the structural role of phosphatidylinositol lipidsin vivo.

Graphical abstract: Lipid membrane curvature induced by distearoyl phosphatidylinositol 4-phosphate

Back to tab navigation

Article information


Submitted
13 Dec 2011
Accepted
18 Jan 2012
First published
02 Feb 2012

Soft Matter, 2012,8, 3090-3093
Article type
Paper

Lipid membrane curvature induced by distearoyl phosphatidylinositol 4-phosphate

S. Furse, N. J. Brooks, A. M. Seddon, R. Woscholski, R. H. Templer, E. W. Tate, P. R. J. Gaffney and O. Ces, Soft Matter, 2012, 8, 3090
DOI: 10.1039/C2SM07358G

Social activity

Search articles by author

Spotlight

Advertisements