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Issue 11, 2012
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Copper-catalyzed decarboxylative C–N coupling for N-arylation

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Abstract

A novel approach for N-arylation utilizing aryl carboxylic acids as stable, inexpensive and widely available arylating reagents was developed. Employing a simple copper(II)–phenanthroline catalyst system, several benzoic acids bearing suitable ortho-substitutions undergo decarboxylative C–N cross-coupling effectively with various N-nucleophiles.

Graphical abstract: Copper-catalyzed decarboxylative C–N coupling for N-arylation

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Supplementary files

Article information


Submitted
14 May 2012
Accepted
14 Jul 2012
First published
16 Jul 2012

Chem. Sci., 2012,3, 3196-3199
Article type
Edge Article

Copper-catalyzed decarboxylative C–N coupling for N-arylation

Y. Zhang, S. Patel and N. Mainolfi, Chem. Sci., 2012, 3, 3196
DOI: 10.1039/C2SC20606D

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