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Issue 1, 2012
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Cooperative Lewis acid/N-heterocyclic carbene catalysis

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Lewis acid activation with N-heterocyclic carbene (NHC) catalysis has presented new opportunities for enantioselective reaction development. Recent findings illustrate that Lewis acids can play an important role in homoenolate annulations by: enhancement of the reactivity, reversal of the diastereo- or regioselectivity, and activation of previously inactive electrophiles. Additionally, the incorporation of a Lewis acid into Brønsted base-catalyzed conjugate addition allowed for an increase in yields.

Graphical abstract: Cooperative Lewis acid/N-heterocyclic carbene catalysis

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Article information

31 Aug 2011
27 Sep 2011
First published
12 Oct 2011

Chem. Sci., 2012,3, 53-57
Article type

Cooperative Lewis acid/N-heterocyclic carbene catalysis

D. T. Cohen and K. A. Scheidt, Chem. Sci., 2012, 3, 53
DOI: 10.1039/C1SC00621E

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