Issue 24, 2012
From the journal:

RSC Advances

Organocatalytic Mannich/cyclization/aromatization sequence: direct synthesis of substituted pyrrole-3-carboxaldehydes†‡

Indresh Kumar,*ab   Nisar A. Mir,a   Panduga Ramarajua  and  Basant P. Wakhlooc  

* Corresponding authors

a Department of Chemistry, Birla Institute of Technology & Science, Rajasthan, Pilani 333 031, India
E-mail: indresh.chemistry@gmail.com, indresh.kumar@bits-pilani.ac.in
Fax: +91 1596 244183
Tel: +91 1596 245073 Ext. 276

b School of Biology & Chemistry, College of Science, Shri Mata Vaishno Devi University, Katra 182 320, India

c Instrumentional Division, IIIM-CSIR Lab, Jammu 180 001, India

Abstract

A robust method for the synthesis of substituted pyrrole-3-carboxaldehydes from N-PMP aldimines and succinaldehyde is reported. This reaction involves an organocatalytic direct Mannich reaction, and an acid catalyzed cyclization and oxidative aromatization sequence with high yields (up to 82%).

Graphical abstract: Organocatalytic Mannich/cyclization/aromatization sequence: direct synthesis of substituted pyrrole-3-carboxaldehydes

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C2RA21258G
Article type
Communication
Submitted
22 Jun 2012
Accepted
08 Aug 2012
First published
08 Aug 2012

RSC Adv., 2012,2, 8922-8925

Permissions

Request permissions

Organocatalytic Mannich/cyclization/aromatization sequence: direct synthesis of substituted pyrrole-3-carboxaldehydes

I. Kumar, N. A. Mir, P. Ramaraju and B. P. Wakhloo, RSC Adv., 2012, 2, 8922 DOI: 10.1039/C2RA21258G

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements