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Issue 15, 2012
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Cu(OTf)2-catalysed Ritter reaction: efficient synthesis of amides from nitriles and halohydrocarbons in water

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Abstract

An efficient and green protocol for the synthesis of amides through the Ritter reaction of nitriles and halohydrocarbons was developed. Cu(OTf)2 economically efficiently catalysed the Ritter reaction in water. A range of halohydrocarbons (benzyl, tert-butyl, sec-alkyl and primary alkyl halohydrocarbons) were coupled with nitriles, providing the corresponding amides.

Graphical abstract: Cu(OTf)2-catalysed Ritter reaction: efficient synthesis of amides from nitriles and halohydrocarbons in water

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Article information


Submitted
15 May 2012
Accepted
16 May 2012
First published
13 Jun 2012

RSC Adv., 2012,2, 6161-6163
Article type
Communication

Cu(OTf)2-catalysed Ritter reaction: efficient synthesis of amides from nitriles and halohydrocarbons in water

G. Qu, Y. Song, H. Niu, H. Guo and J. S. Fossey, RSC Adv., 2012, 2, 6161
DOI: 10.1039/C2RA20941A

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