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Issue 17, 2012
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One-pot build-up procedure for the synthesis of variously substituted purine derivatives

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Abstract

In this article, we report a one-pot build-up procedure leading to 6-chloro- or 2-amino-6-chloropurines bearing various alkyl or aryl substituents in position N-9. This reaction is simple, fast and effective with up to 96% yields depending on the starting amine. This reaction may be easily combined with further nucleophilic displacement of the C-6 chlorine atom using various reagents, making this procedure very attractive in the field of medicinal chemistry pertaining to compounds based on a purine scaffold.

Graphical abstract: One-pot build-up procedure for the synthesis of variously substituted purine derivatives

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Publication details

The article was received on 02 May 2012, accepted on 23 May 2012 and first published on 02 Jul 2012


Article type: Paper
DOI: 10.1039/C2RA20842C
RSC Adv., 2012,2, 6970-6980

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    One-pot build-up procedure for the synthesis of variously substituted purine derivatives

    M. Dejmek, S. Kovačková, E. Zborníková, H. Hřebabecký, M. Šála, M. Dračínský and R. Nencka, RSC Adv., 2012, 2, 6970
    DOI: 10.1039/C2RA20842C

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