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Issue 15, 2012
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Amination of benzylic and cinnamic alcoholsvia a biocatalytic, aerobic, oxidation–transamination cascade

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Abstract

The amination of benzylic and cinnamic alcohols was achieved via a biocatalytic, one-pot oxidation–transamination cascade in aqueous medium at physiological conditions. Alcohol oxidation by galactose oxidase at the expense of O2 furnished the corresponding aldehydes, which were aminated using ω-transaminases in situ. The applicability of this method was demonstrated by a short synthesis of the antifungal agent naftifine.

Graphical abstract: Amination of benzylic and cinnamic alcohols via a biocatalytic, aerobic, oxidation–transamination cascade

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Article information


Submitted
27 Apr 2012
Accepted
02 May 2012
First published
12 Jun 2012

RSC Adv., 2012,2, 6262-6265
Article type
Paper

Amination of benzylic and cinnamic alcohols via a biocatalytic, aerobic, oxidation–transamination cascade

M. Fuchs, K. Tauber, J. Sattler, H. Lechner, J. Pfeffer, W. Kroutil and K. Faber, RSC Adv., 2012, 2, 6262
DOI: 10.1039/C2RA20800H

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