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Issue 7, 2012
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Exploiting the use of ionic liquids to access phosphorodiamidites

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Abstract

A series of phosphorodiamidite reagents have been readily prepared using bis{(trifluoromethyl)sulfonyl}imide based ionic liquids and compared with their syntheses in conventional organic solvents. This method demonstrates a versatile procedure that allows access to both known and novel phosphorodiamidite reagents, whilst addressing issues such as moisture sensitivity and product selectivity present in current molecular based protocols. This method negates the need for reagent purification, whilst allowing for the reactions to be conducted at high concentrations.

Graphical abstract: Exploiting the use of ionic liquids to access phosphorodiamidites

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Publication details

The article was received on 23 Jan 2012, accepted on 23 Jan 2012 and first published on 25 Jan 2012


Article type: Paper
DOI: 10.1039/C2RA20131C
RSC Adv., 2012,2, 2988-2993

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    Exploiting the use of ionic liquids to access phosphorodiamidites

    K. Crossey, C. Hardacre, M. E. Migaud and S. E. Norman, RSC Adv., 2012, 2, 2988
    DOI: 10.1039/C2RA20131C

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