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Issue 9, 2012
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Poly(tris(hydroxymethyl)acrylamidomethane)-based copolymers: a new class of acid-labile thermosensitive polymers

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Abstract

The present contribution reports on an original new class of acid-labile thermosensitive polyacrylamides, namely poly(tris(hydroxymethyl)acrylamidomethane-co-(5-acrylamido-5-hydroxymethyl-2,2-dimethyl-1,3-dioxane)) (P(THAM-co-pTHAM)), in which pTHAM only differed from THAM by an acetal group. The lower critical solution temperature (LCST) was controlled by varying the comonomer composition. Additionally, the properties of these new statistical copolymers were investigated and proved that such chemical structures were interesting for smart applications, notably for drug delivery due to the biocompatibility of low molecular weight PTHAM already demonstrated.

Graphical abstract: Poly(tris(hydroxymethyl)acrylamidomethane)-based copolymers: a new class of acid-labile thermosensitive polymers

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Publication details

The article was received on 05 May 2012, accepted on 29 May 2012 and first published on 30 May 2012


Article type: Paper
DOI: 10.1039/C2PY20309J
Polym. Chem., 2012,3, 2502-2507

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    Poly(tris(hydroxymethyl)acrylamidomethane)-based copolymers: a new class of acid-labile thermosensitive polymers

    S. Monge, S. Antoniacomi, V. Lapinte, V. Darcos and J. Robin, Polym. Chem., 2012, 3, 2502
    DOI: 10.1039/C2PY20309J

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