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Issue 4, 2012
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Terminal functional glycopolymers via a combination of catalytic chain transfer polymerisation (CCTP) followed by three consecutive click reactions

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Abstract

The combination of catalytic chain transfer polymerisation (CCTP) with both thiol-ene and copper catalysed alkyne azide coupling (CuAAC) click chemistry has been employed to give a new route to functional glycopolymers for applications in bioconjugation and biological targeting. Ring opening of poly(glycidyl methacrylate) with sodium azide and subsequent reaction with alkyne functional carbohydrates, as prepared by Fischer glycosylation, has been exploited. This combination of a range of efficient chemistry gives a route to multi gram quantities of glycopolymers avoiding the need for living radical polymerisation chemistry.

Graphical abstract: Terminal functional glycopolymers via a combination of catalytic chain transfer polymerisation (CCTP) followed by three consecutive click reactions

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Publication details

The article was received on 10 Jan 2012, accepted on 26 Jan 2012 and first published on 03 Feb 2012


Article type: Paper
DOI: 10.1039/C2PY20013A
Polym. Chem., 2012,3, 1016-1023

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    Terminal functional glycopolymers via a combination of catalytic chain transfer polymerisation (CCTP) followed by three consecutive click reactions

    Q. Zhang, S. Slavin, M. W. Jones, A. J. Haddleton and D. M. Haddleton, Polym. Chem., 2012, 3, 1016
    DOI: 10.1039/C2PY20013A

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