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Issue 4, 2012
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Polysaccharide-stabilized core cross-linked polymer micelle analogues

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Abstract

A novel approach is presented for the synthesis of block-copolymers that resemble the architecture of a core cross-linked micelle. The polymers are synthesized from a combination of catalytic chain transfer polymerization (CCTP), thiol-Michael addition chemistry and reductive amination. A hydrophobic hyperbranched core is synthesized via CCTP of methyl methacrylate (MMA) and ethylene glycol dimethacrylate (EGDMA), which affords control over the polymer architecture and the degree of chain end-functionality. The vinyl unsaturations of the hyperbranched polymers are converted in nucleophilic pendant amines by thiol-Michael addition using cysteamine hydrochloride. A polysaccharide shell is grafted onto the hyperbranched core via reductive amination with dextran (DEX). The synthesized poly(MMA-co-EGDMA)-b-DEX polymers possess an amphiphilic character, are colloidally stable and resemble the topology of a core cross-linked micelle. The presented methodology provides a robust, modular, and tuneable approach towards the synthesis of amphiphilic core cross-linked micelle analogues.

Graphical abstract: Polysaccharide-stabilized core cross-linked polymer micelle analogues

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Publication details

The article was received on 20 Dec 2011, accepted on 28 Jan 2012 and first published on 03 Feb 2012


Article type: Paper
DOI: 10.1039/C2PY00601D
Polym. Chem., 2012,3, 992-1001

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    Polysaccharide-stabilized core cross-linked polymer micelle analogues

    D. J. Krasznai, T. F. L. McKenna, M. F. Cunningham, P. Champagne and N. M. B. Smeets, Polym. Chem., 2012, 3, 992
    DOI: 10.1039/C2PY00601D

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