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Issue 4, 2012
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Hierarchical self-assembly structures of POSS-containing polypeptide block copolymers synthesized using a combination of ATRP, ROP and click chemistry

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Abstract

In this study, we used a combination of atom transfer radical polymerization, ring opening polymerization, and click chemistry to synthesize new organic/inorganic macromolecular self-assembling building blocks of polystyrene-b-poly(γ-propargyl-L-glutamate-g-polyhedral oligomeric silsesquioxane) [PS-b-(PPLG-g-POSS)]. The incorporation of the PS and POSS units enhanced the α-helical conformation in the solid state, as determined using Fourier transform infrared (FTIR) spectroscopy and wide-angle X-ray diffraction (WAXD). Hierarchical self-assembly of the PS-b-(PPLG-g-POSS) diblock copolymers, which we characterized using WAXD, small-angle X-ray scattering, and transmission electron microscopy, led to the formation of cylindrical structures as a result of microphase separation of the diblock copolymer; the hexagonal cylinder packing nanostructure featured α-helical conformations of polypeptide segments, which were oriented perpendicular to the direction of the cylinder column from diblock copolymers; aggregation of the POSS moieties induced the packing into hexagonal lattice structures. The attachment of POSS units onto the side chains of PPLG stabilized the α-helical secondary structures at elevated temperature, relative to those of pure PPLG and PS-b-PPLG, as determined through temperature-dependent FTIR spectroscopic analyses.

Graphical abstract: Hierarchical self-assembly structures of POSS-containing polypeptide block copolymers synthesized using a combination of ATRP, ROP and click chemistry

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Publication details

The article was received on 05 Dec 2011, accepted on 09 Jan 2012 and first published on 14 Feb 2012


Article type: Paper
DOI: 10.1039/C2PY00574C
Polym. Chem., 2012,3, 882-891

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    Hierarchical self-assembly structures of POSS-containing polypeptide block copolymers synthesized using a combination of ATRP, ROP and click chemistry

    Y. Lin and S. Kuo, Polym. Chem., 2012, 3, 882
    DOI: 10.1039/C2PY00574C

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