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Issue 40, 2012
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Metal-free reactions of alkynes via electrophilic iodocarbocyclizations

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Abstract

Despite attracting tremendous interest over the last few decades, the field of electrophilic cyclizations is still continuously and rapidly developing. Particularly, metal-free reactions that involve the activation of an alkyne using electrophilic halogen sources are powerful tools in the repertoire of synthetic chemists. This brief overview highlights recent progress in C–C bond-forming halocyclizations allowing for the reaction of alkynes with carbon-nucleophiles. Primarily guided by the type of carbon nucleophile, methods are categorized as the addition of arene, malonate, and olefin nucleophiles.

Graphical abstract: Metal-free reactions of alkynes via electrophilic iodocarbocyclizations

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Publication details

The article was received on 01 Aug 2012, accepted on 30 Aug 2012 and first published on 31 Aug 2012


Article type: Emerging Area
DOI: 10.1039/C2OB26508G
Org. Biomol. Chem., 2012,10, 8041-8047

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    Metal-free reactions of alkynes via electrophilic iodocarbocyclizations

    A. Palisse and S. F. Kirsch, Org. Biomol. Chem., 2012, 10, 8041
    DOI: 10.1039/C2OB26508G

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