Jump to main content
Jump to site search

Issue 45, 2012
Previous Article Next Article

Synthesis of 4,6-disubstituted 2-(4-morpholinyl)pyrimidines by cross-coupling reactions using triorganoindium compounds

Author affiliations

Abstract

4,6-Disubstituted-2-(4-morpholinyl)pyrimidines, an important class of bioactive compounds, have been synthesized from 4,6-dichloro-2-(4-morpholinyl)pyrimidine by selective and sequential palladium-catalyzed cross-coupling reactions using triorganoindium reagents. This methodology, being efficient and versatile, allowed the synthesis of a variety of non-symmetrical pyrimidines functionalized at C-4 and C-6 positions.

Graphical abstract: Synthesis of 4,6-disubstituted 2-(4-morpholinyl)pyrimidines by cross-coupling reactions using triorganoindium compounds

Back to tab navigation

Supplementary files

Publication details

The article was received on 18 Jul 2012, accepted on 01 Oct 2012 and first published on 02 Oct 2012


Article type: Paper
DOI: 10.1039/C2OB26398J
Org. Biomol. Chem., 2012,10, 9045-9051

  •   Request permissions

    Synthesis of 4,6-disubstituted 2-(4-morpholinyl)pyrimidines by cross-coupling reactions using triorganoindium compounds

    M. M. Martínez, C. Pérez-Caaveiro, M. Peña-López, L. A. Sarandeses and J. Pérez Sestelo, Org. Biomol. Chem., 2012, 10, 9045
    DOI: 10.1039/C2OB26398J

Search articles by author

Spotlight

Advertisements