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Issue 37, 2012
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An aquatic host–guest complex between a supramolecular G-quadruplex and the anticancer drug doxorubicin

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Abstract

We describe the synthesis of a fluorescent deoxyguanosine derivative that co-assembles (in water) with an unlabeled analogue into a heteromeric supramolecular G-quadruplex, which forms a host–guest complex with doxorubicin as evidenced by FRET experiments.

Graphical abstract: An aquatic host–guest complex between a supramolecular G-quadruplex and the anticancer drug doxorubicin

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Supplementary files

Article information


Submitted
12 May 2012
Accepted
01 Aug 2012
First published
02 Aug 2012

Org. Biomol. Chem., 2012,10, 7562-7565
Article type
Paper

An aquatic host–guest complex between a supramolecular G-quadruplex and the anticancer drug doxorubicin

J. M. Rivera, M. Martín-Hidalgo and J. C. Rivera-Ríos, Org. Biomol. Chem., 2012, 10, 7562 DOI: 10.1039/C2OB25913C

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