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Issue 36, 2012
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From biomass to medicines. A simple synthesis of indolo[3,2-c]quinolines, antimalarial alkaloid isocryptolepine, and its derivatives

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Abstract

Indolo[3,2-c]quinolines are pharmacologically attractive class of heterocyclic compounds. The method of their synthesis, based on transformation of furfural, which is a large-scale product of treatment of biomass including agricultural and forestry wastes, has been developed. This method was utilized for the total synthesis of antimalarial alkaloid isocryptolepine and its derivatives.

Graphical abstract: From biomass to medicines. A simple synthesis of indolo[3,2-c]quinolines, antimalarial alkaloid isocryptolepine, and its derivatives

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Article information


Submitted
01 May 2012
Accepted
06 Jul 2012
First published
09 Jul 2012

Org. Biomol. Chem., 2012,10, 7262-7265
Article type
Communication

From biomass to medicines. A simple synthesis of indolo[3,2-c]quinolines, antimalarial alkaloid isocryptolepine, and its derivatives

M. G. Uchuskin, A. S. Pilipenko, O. V. Serdyuk, I. V. Trushkov and A. V. Butin, Org. Biomol. Chem., 2012, 10, 7262
DOI: 10.1039/C2OB25836F

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