Jump to main content
Jump to site search

Issue 28, 2012
Previous Article Next Article

Antituberculosis agent diaportheone B: synthesis, absolute configuration assignment, and anti-TB activity of its analogues

Author affiliations

Abstract

First synthesis of diaportheone B, an antituberculosis agent isolated from endophytic fungus Diaporthe sp. P133 is reported using two complementary routes, a one step and a three-step sequence. The absolute configuration of diaportheone B was determined by using X-ray crystal structure analysis of its dibromo derivative. In addition, we have prepared several close analogues of diaportheone B and determined their anti-TB potential using Alamar-blue assay (H37Rv).

Graphical abstract: Antituberculosis agent diaportheone B: synthesis, absolute configuration assignment, and anti-TB activity of its analogues

Back to tab navigation

Supplementary files

Publication details

The article was received on 01 May 2012, accepted on 08 May 2012 and first published on 08 May 2012


Article type: Paper
DOI: 10.1039/C2OB25831E
Org. Biomol. Chem., 2012,10, 5385-5394

  •   Request permissions

    Antituberculosis agent diaportheone B: synthesis, absolute configuration assignment, and anti-TB activity of its analogues

    P. Siva Swaroop, G. N. Raut, R. G. Gonnade, P. Verma, R. S. Gokhale and D. Srinivasa Reddy, Org. Biomol. Chem., 2012, 10, 5385
    DOI: 10.1039/C2OB25831E

Search articles by author

Spotlight

Advertisements