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Issue 15, 2012
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Efficient [5 + 1]-strategy for the assembly of 1,8-naphthyridin-4(1H)-ones by domino amination/conjugate addition reactions of 1-(2-chloropyridin-3-yl)prop-2-yn-1-ones with amines

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Abstract

A facile synthetic approach for the synthesis of 1,8-naphthyridine-4(1H)-one derivatives via a catalyst free and Pd-supported tandem amination sequence is developed and described. In a case of aliphatic amines reaction proceeds in a catalyst free mode, however anilines demand Pd-supported reaction conditions.

Graphical abstract: Efficient [5 + 1]-strategy for the assembly of 1,8-naphthyridin-4(1H)-ones by domino amination/conjugate addition reactions of 1-(2-chloropyridin-3-yl)prop-2-yn-1-ones with amines

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Article information


Submitted
04 Dec 2011
Accepted
23 Feb 2012
First published
24 Feb 2012

Org. Biomol. Chem., 2012,10, 2955-2959
Article type
Communication

Efficient [5 + 1]-strategy for the assembly of 1,8-naphthyridin-4(1H)-ones by domino amination/conjugate addition reactions of 1-(2-chloropyridin-3-yl)prop-2-yn-1-ones with amines

V. O. Iaroshenko, I. Knepper, M. Zahid, R. Kuzora, S. Dudkin, A. Villinger and P. Langer, Org. Biomol. Chem., 2012, 10, 2955
DOI: 10.1039/C2OB07030H

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