Issue 15, 2012
From the journal:

Organic & Biomolecular Chemistry

Efficient [5 + 1]-strategy for the assembly of 1,8-naphthyridin-4(1H)-ones by domino amination/conjugate addition reactions of 1-(2-chloropyridin-3-yl)prop-2-yn-1-ones with amines†‡

Viktor O. Iaroshenko,*ab   Ingo Knepper,a   Muhammad Zahid,a   Rene Kuzora,a   Sergii Dudkin,a   Alexander Villingera  and  Peter Langer*ac  

* Corresponding authors

a Institut für Chemie, Universität Rostock, Albert-Einstein-Str. 3a, 18059 Rostock, Germany
E-mail: viktor.iaroshenko@uni-rostock.de
Fax: +0049 381 49864112
Tel: +0049 381 4986410

b National Taras Shevchenko University, 62 Volodymyrska St., Kyiv-33, Ukraine
E-mail: iva108@googlemail.com

c Leibniz-Institut für Katalyse e. V. an der Universität Rostock, Albert-Einstein-Str. 29a, 18059 Rostock, Germany

Abstract

A facile synthetic approach for the synthesis of 1,8-naphthyridine-4(1H)-one derivatives via a catalyst free and Pd-supported tandem amination sequence is developed and described. In a case of aliphatic amines reaction proceeds in a catalyst free mode, however anilines demand Pd-supported reaction conditions.

Graphical abstract: Efficient [5 + 1]-strategy for the assembly of 1,8-naphthyridin-4(1H)-ones by domino amination/conjugate addition reactions of 1-(2-chloropyridin-3-yl)prop-2-yn-1-ones with amines

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Article information

DOI
https://doi.org/10.1039/C2OB07030H
Article type
Communication
Submitted
04 Dec 2011
Accepted
23 Feb 2012
First published
24 Feb 2012

Org. Biomol. Chem., 2012,10, 2955-2959

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Efficient [5 + 1]-strategy for the assembly of 1,8-naphthyridin-4(1H)-ones by domino amination/conjugate addition reactions of 1-(2-chloropyridin-3-yl)prop-2-yn-1-ones with amines

V. O. Iaroshenko, I. Knepper, M. Zahid, R. Kuzora, S. Dudkin, A. Villinger and P. Langer, Org. Biomol. Chem., 2012, 10, 2955 DOI: 10.1039/C2OB07030H

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