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Issue 9, 2012
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Calix[4]arene based 1,3,4-oxadiazole and thiadiazole derivatives: Design, synthesis, and biological evaluation

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Abstract

In the present investigation, we describe some novel calixarene based heterocyclic compounds (5a–5i) in which 1,3,4-oxadiazole and 1,3,4-thiadiazole derivatives have been coupled with 5,11,17,23-tetra-tert-butyl-25,27-bis(chlorocarbonyl-methoxy)-26,28-dihydroxy calix[4]arene. All the newly synthesized calixarene based heterocyclic compounds have been characterized by elemental analysis and various spectroscopic methods like FTIR, 1H NMR, 13C NMR, and FAB-MS. All the final scaffolds have been subjected to antioxidant activity, in vitro antimicrobial screening against two gram (+ve) bacteria (S. aureus, S. pyogenes), two gram (−ve) bacteria (E. coli, P. aeruginosa) and two fungal strains (C. albicans, A. clavatus) and also have been screened for their antitubercular activity against Mycobacterium tuberculosis H37Rv.

Graphical abstract: Calix[4]arene based 1,3,4-oxadiazole and thiadiazole derivatives: Design, synthesis, and biological evaluation

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Article information


Submitted
13 Oct 2011
Accepted
05 Dec 2011
First published
07 Dec 2011

Org. Biomol. Chem., 2012,10, 1785-1794
Article type
Paper

Calix[4]arene based 1,3,4-oxadiazole and thiadiazole derivatives: Design, synthesis, and biological evaluation

M. B. Patel, N. R. Modi, J. P. Raval and S. K. Menon, Org. Biomol. Chem., 2012, 10, 1785
DOI: 10.1039/C2OB06730G

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