Jump to main content
Jump to site search

Issue 42, 2012
Previous Article Next Article

Gas extrusion in natural products total synthesis

Author affiliations


The thermodynamic driving force from the release of a gaseous molecule drives a broad range of synthetic transformations. This review focuses on gas expulsion in key reactions within natural products total syntheses, selected from the past two decades. The highlighted examples survey transformations that generate sulfur dioxide, carbon dioxide, carbonyl sulfide, or nitrogen through polar, radical, pericyclic, photochemical, or organometallic mechanisms. Of particular interest are applications wherein the gas extrusion enables formation of a synthetically challenging motif, such as an unusually hindered or strained bond.

Graphical abstract: Gas extrusion in natural products total synthesis

Back to tab navigation

Publication details

The article was received on 16 Jun 2012 and first published on 09 Aug 2012

Article type: Perspective
DOI: 10.1039/C2OB26152A
Org. Biomol. Chem., 2012,10, 8383-8392

  •   Request permissions

    Gas extrusion in natural products total synthesis

    X. Jiang, L. Shi, H. Liu, A. H. Khan and J. S. Chen, Org. Biomol. Chem., 2012, 10, 8383
    DOI: 10.1039/C2OB26152A

Search articles by author