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Issue 17, 2012
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Lewis acid-mediated radical cyclization: stereocontrol in cascade radical addition–cyclization–trapping reactions

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Abstract

An efficient approach for achieving radical cyclizations by using hydroxamate ester as a coordination tether with Lewis acid was studied. The chiral Lewis acid-mediated cascade radical addition–cyclization–trapping reaction proceeded smoothly with good enantio- and diastereoselectivities, providing various chiral γ-lactams.

Graphical abstract: Lewis acid-mediated radical cyclization: stereocontrol in cascade radical addition–cyclization–trapping reactions

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Supplementary files

Article information


Submitted
11 Jan 2012
Accepted
05 Mar 2012
First published
06 Mar 2012

Org. Biomol. Chem., 2012,10, 3519-3530
Article type
Paper

Lewis acid-mediated radical cyclization: stereocontrol in cascade radical addition–cyclization–trapping reactions

H. Miyabe, R. Asada and Y. Takemoto, Org. Biomol. Chem., 2012, 10, 3519
DOI: 10.1039/C2OB25073J

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