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Issue 12, 2012
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Deracemization of unnatural amino acid: homoalanine using d-amino acid oxidase and ω-transaminase

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Abstract

A deracemization method was developed to generate optically pure L-homoalanine from racemic homoalanine using D-amino acid oxidase and ω-transaminase. A whole cell reaction using a biphasic system converted 500 mM racemic homoalanine to 485 mM L-homoalanine (>99% ee).

Graphical abstract: Deracemization of unnatural amino acid: homoalanine using d-amino acid oxidase and ω-transaminase

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Publication details

The article was received on 22 Dec 2011, accepted on 26 Jan 2012 and first published on 20 Feb 2012


Article type: Paper
DOI: 10.1039/C2OB07161D
Org. Biomol. Chem., 2012,10, 2482-2485

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    Deracemization of unnatural amino acid: homoalanine using D-amino acid oxidase and ω-transaminase

    Y. Seo, S. Mathew, H. Bea, Y. Khang, S. Lee, B. Kim and H. Yun, Org. Biomol. Chem., 2012, 10, 2482
    DOI: 10.1039/C2OB07161D

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