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Issue 9, 2012
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Studies of the H–D exchange mechanism of malonganenone B

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Abstract

Malonganenone B (1) exhibits an unusual H–D exchange of a formyl proton when in deuteric-NMR solvents. Synthetic and kinetic investigations were made to probe the mechanism of this exchange, which appears to occur via an uncommon and transient amineamide NHC intermediate.

Graphical abstract: Studies of the H–D exchange mechanism of malonganenone B

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Publication details

The article was received on 15 Nov 2011, accepted on 08 Dec 2011 and first published on 09 Dec 2011


Article type: Communication
DOI: 10.1039/C2OB06926A
Org. Biomol. Chem., 2012,10, 1725-1729

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    Studies of the H–D exchange mechanism of malonganenone B

    P. G. K. Clark, M. Lein and R. A. Keyzers, Org. Biomol. Chem., 2012, 10, 1725
    DOI: 10.1039/C2OB06926A

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