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Issue 7, 2012
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Olefin cross-metathesis for the synthesis of heteroaromatic compounds

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Abstract

The olefin metathesis reaction has underpinned spectacular achievements in organic synthesis in recent years. Arguably, metathesis has now become the foremost choice for a carboncarbon double bond disconnection. Despite this general utility, de novo routes to heteroaromatic compounds using the cross-metathesis (CM) reaction have only recently emerged as an efficient strategy. This approach allows a convergent union of simple, functionalised, three- to four-carbon olefinic core building blocks, to generate furans, pyrroles and pyridines with a high degree of control of substitution pattern in the product.

Graphical abstract: Olefin cross-metathesis for the synthesis of heteroaromatic compounds

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Article information


Submitted
30 Sep 2011
Accepted
28 Nov 2011
First published
04 Jan 2012

Org. Biomol. Chem., 2012,10, 1322-1328
Article type
Emerging Area

Olefin cross-metathesis for the synthesis of heteroaromatic compounds

T. J. Donohoe, J. F. Bower and L. K. M. Chan, Org. Biomol. Chem., 2012, 10, 1322
DOI: 10.1039/C2OB06659A

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