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Issue 5, 2012
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Triazacyclophane (TAC)-scaffolded histidine and aspartic acid residues as mimics of non-heme metalloenzyme active sites

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Abstract

We describe the synthesis and coordination behaviour to copper(II) of two close structural triazacyclophane-based mimics of two often encountered aspartic acid and histidine containing metalloenzyme active sites. Coordination of these mimics to copper(I) and their reaction with molecular oxygen leads to the formation of dimeric bis(μ-hydroxo) dicopper(II) complexes.

Graphical abstract: Triazacyclophane (TAC)-scaffolded histidine and aspartic acid residues as mimics of non-heme metalloenzyme active sites

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Supplementary files

Article information


Submitted
19 Aug 2011
Accepted
09 Nov 2011
First published
16 Nov 2011

Org. Biomol. Chem., 2012,10, 1088-1092
Article type
Paper

Triazacyclophane (TAC)-scaffolded histidine and aspartic acid residues as mimics of non-heme metalloenzyme active sites

H. B. Albada, F. Soulimani, H. J. F. Jacobs, C. Versluis, B. M. Weckhuysen and R. M. J. Liskamp, Org. Biomol. Chem., 2012, 10, 1088
DOI: 10.1039/C1OB06806G

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