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Issue 8, 2012
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Copper-catalyzed domino intramolecular cyclization: a facile and efficient approach to polycyclic indole derivatives

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Abstract

A mild and efficient Cu2O-catalyzed domino intramolecular C–N coupling/C–Y (Y = O, S, N) bond formation was successfully achieved. Thus oxazino[3,2-a]indole, thiazino[3,2-a]indole and indolo[2,1-b]quinazoline derivatives were facilely assembled from readily accessible gem-dibromovinyl systems. The protocol is general and practical, affording a variety of the indole-incorporated products in good to excellent yields even under air atmosphere.

Graphical abstract: Copper-catalyzed domino intramolecular cyclization: a facile and efficient approach to polycyclic indole derivatives

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Publication details

The article was received on 30 Aug 2011, accepted on 16 Nov 2011 and first published on 16 Nov 2011


Article type: Paper
DOI: 10.1039/C1OB06488F
Org. Biomol. Chem., 2012,10, 1602-1611

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    Copper-catalyzed domino intramolecular cyclization: a facile and efficient approach to polycyclic indole derivatives

    Z. Xia, K. Wang, J. Zheng, Z. Ma, Z. Jiang, X. Wang and X. Lv, Org. Biomol. Chem., 2012, 10, 1602
    DOI: 10.1039/C1OB06488F

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