Jump to main content
Jump to site search

Issue 2, 2012
Previous Article Next Article

Squaramide-catalyzed enantioselective Michael addition of malononitrile to chalcones

Author affiliations

Abstract

A highly enantioselective Michael addition of malononitrile to chalcones catalyzed by a chiral quinine-derived squaramide catalyst has been developed. This organocatalytic reaction at a very low catalyst loading (0.5 mol%) led to chiral γ-cyano carbonyl compounds in good yields with high enantioselectivities (up to 96% ee) under mild reaction conditions.

Graphical abstract: Squaramide-catalyzed enantioselective Michael addition of malononitrile to chalcones

Back to tab navigation

Supplementary files

Publication details

The article was received on 31 Jul 2011, accepted on 28 Sep 2011 and first published on 09 Nov 2011


Article type: Paper
DOI: 10.1039/C1OB06302B
Org. Biomol. Chem., 2012,10, 332-338

  •   Request permissions

    Squaramide-catalyzed enantioselective Michael addition of malononitrile to chalcones

    W. Yang, Y. Jia and D. Du, Org. Biomol. Chem., 2012, 10, 332
    DOI: 10.1039/C1OB06302B

Search articles by author

Spotlight

Advertisements