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Issue 2, 2012
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Squaramide-catalyzed enantioselective Michael addition of malononitrile to chalcones

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Abstract

A highly enantioselective Michael addition of malononitrile to chalcones catalyzed by a chiral quinine-derived squaramide catalyst has been developed. This organocatalytic reaction at a very low catalyst loading (0.5 mol%) led to chiral γ-cyano carbonyl compounds in good yields with high enantioselectivities (up to 96% ee) under mild reaction conditions.

Graphical abstract: Squaramide-catalyzed enantioselective Michael addition of malononitrile to chalcones

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Article information


Submitted
31 Jul 2011
Accepted
28 Sep 2011
First published
09 Nov 2011

Org. Biomol. Chem., 2012,10, 332-338
Article type
Paper

Squaramide-catalyzed enantioselective Michael addition of malononitrile to chalcones

W. Yang, Y. Jia and D. Du, Org. Biomol. Chem., 2012, 10, 332 DOI: 10.1039/C1OB06302B

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