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Issue 22, 2012
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Anticancer effect and mechanism of polymer micelle-encapsulated quercetin on ovarian cancer

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Abstract

Encapsulation of hydrophobic agents in polymer micelles can improve the water solubility of cargos, contributing to develop novel drugs. Quercetin (QU) is a hydrophobic agent with potential anticancer activity. In this work, we encapsulated QU into biodegradable monomethoxy poly(ethylene glycol)-poly(ε-caprolactone) (MPEG-PCL) micelles and tried to provide proof-of-principle for treating ovarian cancer with this nano-formulation of quercetin. These QU loaded MPEG-PCL (QU/MPEG-PCL) micelles with drug loading of 6.9% had a mean particle size of 36 nm, rendering the complete dispersion of quercetin in water. QU inhibited the growth of A2780S ovarian cancer cells on a dose dependent manner in vitro. Intravenous administration of QU/MPEG-PCL micelles significantly suppressed the growth of established xenograft A2780S ovarian tumors through causing cancer cell apoptosis and inhibiting angiogenesis in vivo. Furthermore, the anticancer activity of quercetin on ovarian cancer cells was studied in vitro. Quercetin treatment induced the apoptosis of A2780S cells associated with activating caspase-3 and caspase-9. MCL-1 downregulation, Bcl-2 downregulation, Bax upregulation and mitochondrial transmembrane potential change were observed, suggesting that quercetin may induce apoptosis of A2780S cells through the mitochondrial apoptotic pathway. Otherwise, quercetin treatment decreased phosphorylated p44/42 mitogen-activated protein kinase and phosphorylated Akt, contributing to inhibition of A2780S cell proliferation. Our data suggested that QU/MPEG-PCL micelles were a novel nano-formulation of quercetin with a potential clinical application in ovarian cancer therapy.

Graphical abstract: Anticancer effect and mechanism of polymer micelle-encapsulated quercetin on ovarian cancer

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Publication details

The article was received on 07 Aug 2012, accepted on 07 Sep 2012 and first published on 11 Sep 2012


Article type: Paper
DOI: 10.1039/C2NR32181E
Nanoscale, 2012,4, 7021-7030

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    Anticancer effect and mechanism of polymer micelle-encapsulated quercetin on ovarian cancer

    X. Gao, B. Wang, X. Wei, K. Men, F. Zheng, Y. Zhou, Y. Zheng, M. Gou, M. Huang, G. Guo, N. Huang, Z. Qian and Y. Wei, Nanoscale, 2012, 4, 7021
    DOI: 10.1039/C2NR32181E

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