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Issue 15, 2012
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Multi-photon imaging of amine-functionalized silica nanoparticles

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A convenient and simple strategy for preparing water soluble, photoluminescent functionalized silica nanoparticles (M-dots) in the absence of fluorophores or metal doping is demonstrated. These M-dots can be used for bioimaging using one and two-photon microscopy. Because of their high photostability, low toxicity and high biocompatibility compared with Lumidot™ CdSe/ZnS quantum dots, functionalized silica particles are superior alternatives for current bioimaging platforms. Moreover, the presence of a free amine group at the surface of the M-dots allows biomolecule conjugation (e.g. with antibodies, proteins) in a single step for converting these photoluminescent SiO2 nanoparticles into multifunctional efficient vehicles for theragnostics.

Graphical abstract: Multi-photon imaging of amine-functionalized silica nanoparticles

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Publication details

The article was received on 19 Mar 2012, accepted on 17 Apr 2012 and first published on 03 May 2012

Article type: Paper
DOI: 10.1039/C2NR30660C
Nanoscale, 2012,4, 4680-4686

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    Multi-photon imaging of amine-functionalized silica nanoparticles

    F. Natalio, A. Kashyap, S. Lorenz, H. Kerschbaumer, M. Dietzsch, M. N. Tahir, H. Duschner, S. Strand, D. Strand and W. Tremel, Nanoscale, 2012, 4, 4680
    DOI: 10.1039/C2NR30660C

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