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Issue 9, 2012
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Lasso peptides: structure, function, biosynthesis, and engineering

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Abstract

Covering: up to May 2012

Lasso peptides are a class of ribosomally-synthesized and posttranslationally-modified natural products with diverse bioactivities. This review describes the structure and function of all known lasso peptides (as of mid-2012) and covers our current knowledge about the biosynthesis of those molecules. The isolation and characterization of lasso peptides are also covered as are bioinformatics strategies for the discovery of new lasso peptides from genomic sequence data. Several studies on the engineering of new or improved function into lasso peptides are highlighted, and unanswered questions in the field are also described.

Graphical abstract: Lasso peptides: structure, function, biosynthesis, and engineering

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Article information


Submitted
16 Jun 2012
First published
25 Jul 2012

Nat. Prod. Rep., 2012,29, 996-1006
Article type
Review Article

Lasso peptides: structure, function, biosynthesis, and engineering

M. O. Maksimov, S. J. Pan and A. James Link, Nat. Prod. Rep., 2012, 29, 996
DOI: 10.1039/C2NP20070H

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