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Issue 9, 2012
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The nonribosomal synthesis of diketopiperazines in tRNA-dependent cyclodipeptide synthase pathways

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Abstract

Covering: up to 2012

We review here work on the biosynthesis of diketopiperazines (DKPs), a large class of natural products with noteworthy biological activities, focusing on the biosynthetic pathways involving cyclodipeptide synthases (CDPSs), a newly defined family of enzymes. Distinct from nonribosomal peptide synthetases (NRPSs), the other family of enzymes synthesizing DKPs, CDPSs bridge the primary and secondary metabolic pathways by hijacking aminoacyl-tRNAs to produce DKPs. This review includes a comprehensive description of the state of the art for CDPS-dependent pathways, and highlights the ways in which this knowledge could be used to increase the diversity of natural DKPs by pathway engineering.

Graphical abstract: The nonribosomal synthesis of diketopiperazines in tRNA-dependent cyclodipeptide synthase pathways

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Publication details

The article was received on 27 Jan 2012 and first published on 03 Jul 2012


Article type: Review Article
DOI: 10.1039/C2NP20010D
Nat. Prod. Rep., 2012,29, 961-979

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    The nonribosomal synthesis of diketopiperazines in tRNA-dependent cyclodipeptide synthase pathways

    P. Belin, M. Moutiez, S. Lautru, J. Seguin, J. Pernodet and M. Gondry, Nat. Prod. Rep., 2012, 29, 961
    DOI: 10.1039/C2NP20010D

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