Jump to main content
Jump to site search

Issue 5, 2012
Previous Article Next Article

Oxadiazole isomers: all bioisosteres are not created equal

Author affiliations

Abstract

Two series of amino-substituted 1,2,4- and 1,3,4-oxadiazole matched compounds were evaluated and found to have significant differences in their various physical and pharmaceutical properties. Experimental and computational techniques suggested that variation in hydrogen bond acceptor and donor strength were responsible for these effects.

Graphical abstract: Oxadiazole isomers: all bioisosteres are not created equal

Back to tab navigation

Supplementary files

Article information


Submitted
22 Feb 2012
Accepted
15 Mar 2012
First published
16 Mar 2012

Med. Chem. Commun., 2012,3, 600-604
Article type
Concise Article

Oxadiazole isomers: all bioisosteres are not created equal

K. Goldberg, S. Groombridge, J. Hudson, A. G. Leach, P. A. MacFaul, A. Pickup, R. Poultney, J. S. Scott, P. H. Svensson and J. Sweeney, Med. Chem. Commun., 2012, 3, 600
DOI: 10.1039/C2MD20054F

Search articles by author

Spotlight

Advertisements