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Issue 3, 2012
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Antimalarialperoxides: advances in drug discovery and design

Rachel D. Slack,a   Alexander M. Jacobinea  and  Gary H. Posner*ab  
Author affiliations

* Corresponding authors

a Department of Chemistry, School of Arts and Sciences, The Johns Hopkins University, 3400 North Charles Street, Baltimore, Maryland, USA
E-mail: ghp@jhu.edu
Tel: +410-516-4670

b The Johns Hopkins Malaria Research Institute, Bloomberg School of Public Health, Baltimore, Maryland, USA

Abstract

Cyclic peroxides such as the plant-derived 1,2,4-trioxane artemisinin and its derivatives are short-lived, rapidly-acting antimalarials that are now usually combined with standard long-lived, alkaloidal antimalarials; such artemisinin combination therapy (ACT) is the worldwide standard operating procedure for malaria chemotherapy. This review discusses antimalarial monomeric and dimeric derivatives of artemisinin, peroxides not derived from artemisinin, and finally hybrids containing one peroxide unit covalently linked to a non-peroxide unit. Emphasis is placed on the antimalarial effectiveness of these diverse cyclic peroxides and on the simplicity of their synthesis.

Graphical abstract: Antimalarial peroxides: advances in drug discovery and design

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Article information

https://doi.org/10.1039/C2MD00277A
Submitted
02 Nov 2011
Accepted
06 Dec 2011
First published
07 Dec 2011
Med. Chem. Commun., 2012,3, 281-297
Article type
Review Article
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Antimalarial peroxides: advances in drug discovery and design

R. D. Slack, A. M. Jacobine and G. H. Posner, Med. Chem. Commun., 2012, 3, 281
DOI: 10.1039/C2MD00277A

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