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Issue 9, 2012
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Nuclear (PET/SPECT) and optical imaging probes targeting the CXCR4 chemokine receptor

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Abstract

The chemokine receptor CXCR4 has been found to be highly expressed in a wide variety of cancer types, including breast, colorectal, melanoma, nasopharyngeal, oesophageal, osteosarcoma, and non-small-cell lung carcinoma. It has been shown that these elevated expression levels are yet further increased upon metastasis. This receptor therefore represents a highly attractive target which could facilitate the diagnostic imaging of many aggressive cancers. Since 2005, there have been a wide assortment of CXCR4-targeting imaging probes spanning both nuclear (PET/SPECT) and optical imaging modalities. This review highlights a wide variety of pertinent examples from the recent literature, placing special focus on the chemical aspects of probe design.

Graphical abstract: Nuclear (PET/SPECT) and optical imaging probes targeting the CXCR4 chemokine receptor

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Publication details

The article was received on 08 Feb 2012, accepted on 06 Jul 2012 and first published on 23 Jul 2012


Article type: Review Article
DOI: 10.1039/C2MD20117H
Med. Chem. Commun., 2012,3, 1039-1053

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    Nuclear (PET/SPECT) and optical imaging probes targeting the CXCR4 chemokine receptor

    J. C. Knight and F. R. Wuest, Med. Chem. Commun., 2012, 3, 1039
    DOI: 10.1039/C2MD20117H

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