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Issue 8, 2012
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Biochemical and biosynthetic preparation of natural product-like cyclic peptide libraries

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Abstract

Cyclic peptides are at the forefront of efforts to pursue previously ‘undruggable’ therapeutic targets. Increasingly, researchers are adapting natural products and their biosynthetic systems to the preparation of cyclic peptide libraries. Alternatively, extant biotechnologies are being modified to increase the range and diversity of the compounds that they can access and incorporate into natural product motifs. A number of such systems have been validated with lead discovery and optimization against therapeutically relevant targets.

Graphical abstract: Biochemical and biosynthetic preparation of natural product-like cyclic peptide libraries

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Publication details

The article was received on 06 Mar 2012, accepted on 04 May 2012 and first published on 09 May 2012


Article type: Review Article
DOI: 10.1039/C2MD20068F
Med. Chem. Commun., 2012,3, 905-915

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    Biochemical and biosynthetic preparation of natural product-like cyclic peptide libraries

    A. A. Bowers, Med. Chem. Commun., 2012, 3, 905
    DOI: 10.1039/C2MD20068F

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